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PSILOCYBIN(Magic Mushrooms)

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Psilocybin (4-phosphoryloxy-N , N-dimethyltryptamine) and Psilokin are chemical compounds produced in Mexico, South America and the regions of the United States from certain varieties of dried and fresh hallucinogenic mushrooms. Indole-alkylamine (tryptamine) is known as psilocybin. Such compounds have a similar structure to diethylamide (LSD) lysergic acid and are misused to create a  The effects on the Central Nervous System Serotonin (5-HT) receptors are possibly caused by hallucinogenic (psychedelic) drugs. You can buy PSILOCYBIN online and get PSILOCYBIN for sale online. More than 180 mushroom species contain psilocybin or psilocin chemicals. Hallucinogenic mushrooms, including peyote (mescaline), have been used over centuries in indigenous and religious ceremonies. The lab can also develop psilocybin and psilocin synthetically. There have been rumors of other LSD-laced mushroom species being psilocybins that were purchased on the markets.

How to Use Magic Mushroom?

Magic Mushrooms have long and slender stems with dark gill on the underside, which can look white or greyish and can be hidden by caps. Dried mushrooms are generally of a rust-brown reddish color with isolated off-white areas. Mushrooms can be taken orally and made to a tea or mixed in other foodstuffs. Fresh or dried product may be used in mushrooms. There’s an unpleasant taste of psilocybin. Any dose of psilocybin may cause a & bad trips or an uncomfortable or even terrifying experience. Dry mushrooms typically contain approximately 0.2% to 0.4% psilocybin, and traces only psilocin levels. The average psilocybin dose that is used for recreation varies with peak effects in 1 to 2 hours and a period of approximately 6 hours. Depending on mushroom type, preparation method, and tolerance, the dose andeffects can vary greatly. The specific types of mushrooms or how much hallucinogen each mushroom produces can be difficult to determine. If you choose to use psilocybine for recreation, initial smaller doses and a longer time to assess the effects may be a safer option.

Medical Use

While psilocybin was used in rituals over the years, recent clinical studies have also been documented in modern medicine. In the Psychopharmacology Journal, a paper describing two small studies showing the ingredient in  magic mushrooms (psilocybin), the feeling of “existential pain, which patients frequently encounter after being treated for cancer, is written. Cancer will reportedly leave patients with this kind of psychiatric illness with the feeling that life is meaningless. It may not be sufficient to provide traditional therapies as antidepressants. Nevertheless, a single dose of psilocybine in synthetic form reversed the patients pain and has become a long-term consequence.

MAGIC MUSHROOM GROWKITS

Grow your own magic mushrooms at home with magic mushroom grow kits. Each tub provides multiple flushes of fruiting bodies in a matter of weeks. Gone are the days of scouring woodlands and pastures—or relying on shady dealers—to acquire a dose of goodness!

Our selection of grow kits offers something for everyone. If you’re new to magic mushrooms, try out one of our less potent strains for a gentle introduction. In contrast, you’ll need something a little stronger if you want to blast off and explore alternate dimensions. You’ll get a general idea of the potency of each strain by reading the description of a particular grow kit.

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Wenn man Magic Mushrooms bestellen möchte, ist die Frage nach der Legalität immer ein heisses Thema.

Es gibt eine gewisse rechtliche Grauzone, bei der Bestellung von Magic Mushrooms, aber wenn man bescheid weiss was legal ist und was nicht kann man, ohne Zoll und rechtliche Gefahren fürchten zu müssen, im Internet Magic Mushrooms bestellen. Wie diese rechtliche Grauzone im Detail aussieht, erklären wir im Anschluss.

Can Microdosing Psychedelics Improve Your Mental Health?

When you hear the term “psychedelics,” you might think of hallucinogenic and mystical experiences. Popular psychedelics include LSD (lysergic acid diethylamide), magic mushrooms (containing the psychedelic psilocybin), and DMT (N,N-dimethyltryptamine, part of the spiritual medicine ayahuasca), all of which can cause intense psychological experiences colloquially known as “trips.” However, there is an emerging push within the scientific community to study these known recreational drugs as treatments for psychiatric conditions that could potentially be more effective with fewer side effects than traditional psychiatric medications.

This psychiatric interest in psychedelics is nothing new: in the 1950s and 60s, thousands of patients were experimentally given various psychedelics to treat alcoholism and other mental health disorders. It was only when the U.S. 1971 Controlled Substances Act was passed that much of this research came to a grinding halt. After a nearly 40 year pause in this work, scientists are beginning to resume this research. Landmark trials from 2014 and 2016 have already shown that LSD and psilocybin respectively improved mood and anxiety in patients with various life-threatening illnesses for up to a year after treatment, with many more studies underway.

Alongside this renewed interest in psychedelics is an increasing popular approach known as microdosing. Microdosing is when patients take a dose of psychedelics that is too small to produce any perceptible effects, generally between 5 to 10% of a standard dose. Despite the small amount of drug taken, there is evidence to suggest that microdosing can still bring about some of the benefits observed with full-dose treatment without causing the intense and sometimes negative hallucinatory experiences. Nevertheless, some scientists are skeptical that these results are spurious, or worse, that microdosing may even be harmful.

The potential mechanisms of microdosing

Figure 1: One potential mechanism for psychedelic drugs. The drug may bind to a molecular region known as the serotonin 2A receptor, and cause the cortex to become excited and form new neuronal connections. 

Psychedelics are known to primarily affect serotonin, a chemical messenger that helps nerve cells communicate with other cells in the body. Serotonin is popularly portrayed in the media as being responsible for happiness, but in reality, its functionality is much more complex and widespread. In fact, serotonin is associated not just with mood, but also with cognition, sleeping, eating, thermoregulation, memory, and even physiological processes like vomiting.

Since serotonin is so widely important in the body, there are molecular regions called serotonin 2A receptors located throughout the central nervous system. Chemicals can bind to these receptors in order to stimulate or block the serotonin system. Although this mechanism is not fully understood, these receptors are believed to be the targets of psychedelics. One hypothesis is that when these drugs bind to the serotonin 2A receptors, the brain cortex, responsible for cognitive, sensory, and motor functions, becomes excited, ultimately leading to hallucinations and other effects. Some studies have even found psychedelics to increase neuroplasticity, which leads to the creation of more connections between neurons and could potentially explain the novelty of these intense psychological experiences. Microdosing is thus theorized to work in the same fashion, albeit to a milder degree.

Some research also suggests that microdosing may work by fighting inflammation in the body. Inflammation is the result of the body’s immune system protecting you from infection, but can cause damage when the immune system is activated without any real danger. Long-lasting or chronic inflammation is implicated in a number of disorders, including auto-immune diseases and even mental health conditions like depression. Studies on animals have shown anti-inflammatory effects from microdosing, leading some scientists to speculate that this could point to another potential mechanism of action.

The early research on microdosing

Research on microdosing is still new, and thus there are a relatively limited number of studies available to understand its effects on humans. As for 2020, the first clinical trials exploring microdosing as a treatment for mental health conditions are now underway. Until those results are available, most human research has been limited to surveys of those who have tried microdosing on their own.

These survey results have largely been positive. For example, in one international survey, 79% of respondents reported improvements in their mental health after microdosing. In other surveys, participants described experiencing better creativity and productivity, in addition to decreased levels of anxiety and depression. Although promising, these results must be taken with a grain of salt. Because these are surveys, there is no way to confirm or enforce the dosage, scheduling, and type of psychedelic used, and indeed, some studies have already noted that experiences can vary depending on these factors. Moreover, these results are susceptible to the so-called placebo effect, in which just the knowledge that you are taking some kind of a treatment can cause you to experience benefits, even if the treatment is not directly causally related to the effects. If this is the case, then microdosing might have very little to do with the reported improvements.

Figure 2: In one experiment, microdosed rats continued attempting to escape a pool even after a long period of time, whereas untreated rats gave up in the same time interval.

There has been some animal research to back these survey findings. In one prominent study, researchers at UC Davis administered microdoses of DMT to rats and observed responses similar to those arising from antidepressants. Both microdosed and untreated rats were placed in a pool with no escape, and the microdosed rats continued swimming in an attempt to escape after the untreated rats had already given up. This suggests some degree of improved resilience and optimism in the microdosed rats. Another study microdosed some rats with psilocin (another psychoactive component of magic mushrooms) and others with a different psychedelic called ketamine, and found both to mildly alleviate anxiety in rats experiencing a stressful maze.

Results from animal research, of course, are not automatically transferable to humans. Nevertheless, these findings suggest that beneficial effects from psychedelics are plausible, spurring greater motivation for ongoing clinical trial research.

Safety concerns

The question, however, is not just whether microdosing is effective, but also whether it’s safe. Until clinical trials are complete, we will not have a full answer, but there is already research to suggest that certain people may be vulnerable to negative side effects. In particular, some people may have psychotic episodes or other mental health issues triggered by taking psychedelics, especially if they have a history of psychosis or pre-existing risk for serious psychiatric disorders like schizophrenia or bipolar disorder. Although microdosing involves a much lower amount of the drug, it is still possible that the negative consequences may hold true.

Furthermore, survey research has revealed side effects specific to microdosing. Some people have reported unwanted symptoms such as migraines, over-stimulation, difficulty sleeping, physical discomfort, and sometimes even anxiety, despite the promise of these drugs to alleviate it. It is not yet well-understood how these symptoms relate to the exact dosage, scheduling, and type of drug taken, but they do show that negative effects can potentially occur.

All in all, it is still far too early to say whether microdosing is a viable way to harness the potential of psychedelics for mental health treatment. Much more research needs to be done to understand not only how it works, but what the potential consequences and side effects are. If clinical trials confirm the safety and efficacy of microdosing psychedelics, these could represent a new avenue for mental health treatment.

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